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Angiology

Protein tyrosine phosphatase inhibition improves vascular endothelial dysfunction

Published in Obesity and Diabetes Week, April 17th, 2006

Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction in diabetes mellitus and hyperhomocysteinemia patients.

According to a report from India, "The study has been designed to investigate the effect of Bis-(maltolato) oxovanadium (BMOV), an inhibitor of protein tyrosin phosphatase (PTPase), in diabetes mellitus and hyperhomocysteinemia-induced vascular endothelial dysfunction."

D.I. Shah and M. Singh working with Punjabi University described their procedure, "Streptozotocin (55 mg kg-1, i.v.) and methionine (1.7% w/w, p.o., 4 weeks) were administered to rats to produce diabetes mellitus (serum glucose >140...

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