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Diabetes Therapy

Incretin mimetics and dipeptidyl peptidase-IV inhibitors offer new type 2 diabetes therapies

Published in Obesity and Diabetes Week, April 24th, 2006

Incretin mimetics and dipeptidyl peptidase-IV inhibitors offer potential new therapies for type 2 diabetes mellitus.

According to a recent review from the United States, "The emergence of the glucoregulatory hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide has expanded our understanding of glucose homeostasis. In particular, the glucoregulatory actions of the incretin hormone GLP-1 include enhancement of glucose-dependent insulin secretion, suppression of inappropriately elevated glucagon secretion, slowing of gastric emptying, and reduction of food intake."

C. Triplitt and colleagues working with the...

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