Published in Obesity and Diabetes Week, May 1st, 2006
Study 1: Metabolic control may be improved by targeting the BA-TGR5-cAMP-D2 signaling pathway.
According to recent research from France, "While bile acids (BAs) have long been known to be essential in dietary lipid absorption and cholesterol catabolism, in recent years an important role for BAs as signaling molecules has emerged. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor (GPCR) TGR5 and activate nuclear hormone receptors such as farnesoid X receptor alpha (FXR-alpha; NR1H4)."
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