Obesity
Reports from the United States and Canada advance knowledge in obesity research
Published in Obesity and Diabetes Week, May 1st, 2006
Study 1: Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in leptin-deficient and leptin-resistant murine models of obesity.
"Disruption of leptin signaling is associated with obesity, heart failure, and cardiac hypertrophy, but the role of leptin in cardiac myocyte apoptosis is unknown. We tested the hypothesis that apoptosis increases in leptin-deficient ob/ob and leptin-resistant db/db mice and is associated with aging and left ventricular hypertrophy, increased DNA damage, and decreased survival," scientists in the United States...
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