Obesity Pathogenesis
Adapter p62 is linked to mature-onset obesity and insulin resistance in mouse model
Published in Obesity and Diabetes Week, May 1st, 2006
According to recent research published in the journal Cell Metabolism, "Signaling cascades that control adipogenesis are essential in the regulation of body weight and obesity. The adaptor p62 controls pathways that modulate cell differentiation. We report here that p62-/- mice develop mature-onset obesity, leptin resistance, as well as impaired glucose and insulin intolerance."
"The metabolic rate was significantly reduced in p62-/- nonobese mice, which displayed increased mRNA levels of PPAR-gamma and reduced levels of...
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