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Obesity Therapy

Selective 5-HT2C agonists show promise in obesity treatments

Published in Obesity and Diabetes Week, May 1st, 2006

Selective 5-HT2C agonists show promise in obesity treatments.

"Activation of central 5-HT2C receptors as a strategy for appetite suppression and weight control is supported by animal pharmacology and human clinical studies. Considerable evidence comes from the weight-loss effects of fenfluramine, a nonselective 5-HT2C agonist," scientists in the United States report in their review.

"Advances in molecular pharmacology have led to an understanding of the effects of 5-HT2C receptor activation on food intake and satiety, in addition to providing insight into the causes of cardiac valvular insufficiency and...

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