Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

According to a study from the United States, "Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty acids to a glycerol backbone, with unique enzymes required to catalyze each acylation step. Acylation at the sn-2 position requires 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) activity. To date, seven Agpat genes have been identified based on activity and/or sequence similarity, but their physiological functions have not been well established."

L. Vergnes and colleagues working with the University of California in Los Angeles...

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