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Obesity Pathogenesis

ENPP1, an insulin receptor inhibitor, is a genetic link between obesity and diabetes

Published in Obesity and Diabetes Week, May 15th, 2006

ENPP1, an inhibitor of the insulin receptor, is a genetic link between childhood and adult obesity and type 2 diabetes.

According to recent research from France, "Clinical studies have established the strong link between obesity and type 2 diabetes, especially in children, where the rising prevalence of childhood severe obesity has preceded the recent emergence of early-onset forms of 'diabesity'. These data suggested a common genetic background shared by both conditions, which was also supported by the identification by genome scans of several diabesity chromosomal regions of linkage."

"The genetic investigation of early-onset form of familial...

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