Diabetes Gene Therapy
Type 1 diabetes genetic susceptibility is demonstrated by in vivo RNA interference
Published in Obesity and Diabetes Week, May 15th, 2006
"Type 1 diabetes is an autoimmune disease influenced by multiple genetic loci. Although more than 20 insulin-dependent diabetes (Idd) loci have been implicated in the nonobese diabetic (NOD) mouse model, few causal gene variants have been identified," wrote S. Kissler and colleagues, Massachusetts Institute of Technology (MIT).
"Here we show that RNAi can be used to probe candidate genes in this disease model. Slc11a1 encodes a phagosomal ion transporter, Nramp1, that affects resistance to intracellular pathogens and...
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