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Diabetes Therapy

Insulin secretion may be a major determinant of diabetic control in overt type 2 diabetics

Published in Obesity and Diabetes Week, May 15th, 2006

Insulin secretion appears to determine diabetes control in type 2 diabetic patients treated with metformin alone or with combined metformin and glyburide.

"Defects in insulin secretion and sensitivity, two major determinants of glycemic control, can occur and progress or not in parallel. The present study was designed to compare the respective roles of both determinants on HbA1c, in type 2 diabetic patients, according to whether or not residual beta-cell function was stimulated with insulin secretagogues," scientists writing in the European Journal of Clinical Investigation report.

L. Monnier and colleagues working with the Hopital Lapeyronie...

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