Endocrinology
PC-1 likely plays a role in insulin resistance and hyperglycemia
Published in Obesity and Diabetes Week, May 22nd, 2006
"The ectoenzyme PC-1 is an insulin receptor inhibitor that is elevated in cells and tissues of humans with type 2 diabetes (T2D). We have recently shown that acute PC-1 overexpression in liver causes insulin resistance and glucose intolerance in mice (3), but the chronic effects of PC-1 overexpression on these functions are unknown. Herein we produced transgenic mice overexpressing the potent q allele of human PC-1 in muscle and liver," scientists in the United States report.
"Compared with controls, these mice had 2- to 3-fold elevations of PC-1 content...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
More Articles from Obesity and Diabetes Week
- Genetics & Genomics
Anthocyanins can regulate adipocytokine gene expression in obesity and diabetes - Obesity
BNP and N-terminal pro-BNP linked to gastric bypass surgery history in obese patients - Obesity
Cytokines promote Wnt signaling and inflammation in 3T3-L1 preadipocytes - Obesity Complications
Waist-to-hip ratio is important marker of endothelial dysfunction across wide BMI range - Obesity Therapy
Angiotensin AT1 receptor blockage improves renal function survival of obese Zucker rats - Anesthesia
Supraclavicular block success rate linked to obesity - More from this issue of Obesity and Diabetes Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
