Published in Obesity and Diabetes Week, May 22nd, 2006
"The ectoenzyme PC-1 is an insulin receptor inhibitor that is elevated in cells and tissues of humans with type 2 diabetes (T2D). We have recently shown that acute PC-1 overexpression in liver causes insulin resistance and glucose intolerance in mice (3), but the chronic effects of PC-1 overexpression on these functions are unknown. Herein we produced transgenic mice overexpressing the potent q allele of human PC-1 in muscle and liver," scientists in the United States report.
"Compared with controls, these mice had 2- to 3-fold elevations of PC-1 content...
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