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Cardiovascular Disease

Insulin stimulates arterial neointima formation after balloon injury

Published in Obesity and Diabetes Week, May 22nd, 2006

Insulin stimulates arterial neointima formation after balloon injury in normal rats.

"Insulin resistance in patients is associated with increased atherosclerosis and arterial restenosis. It is thought that the concomitant hyperinsulinemia exacerbates vascular disease because resistance to insulin-induced glucose disposal is associated with resistance to certain effects of insulin which inhibit, but with no resistance to other effects which promote, neointimal hyperplasia," investigators in the United States report.

E. Foster and associates at the University of Texas explained, "We sought to determine the net effect of hyperinsulinemia on neointimal...

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