Diabetes Pathogenesis
alpha2 -Heremans-Schmid glycoprotein is linked to insulin resistance and fat accumulation
Published in Obesity and Diabetes Week, May 29th, 2006
According to a study from Germany, "The alpha2 -Heremans-Schmid glycoprotein (AHSG Fetuin-A in animals) impairs insulin signaling in vitro and in rodents. Whether AHSG is associated with insulin resistance in humans is under investigation. In an animal model of diet-induced obesity that is commonly associated with hepatic steatosis, an increase in Ahsg mRNA expression was observed in the liver. Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be...
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