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Diabetes Pathogenesis

PPARG Pro12Ala variant linked to a lower risk of developing hyperglycemia over 6 years

Published in Obesity and Diabetes Week, May 29th, 2006

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years.

According to a study from France, "Although cross-sectional studies have associated the Pro12Ala polymorphism of PPARG with type 2 diabetes, prospective studies offer more opportunities to investigate genetic variants. Associations between PPARG polymorphisms with insulin resistance parameters and with the 6-year incidence of impaired fasting glucose or type 2 diabetes were tested in 3,914 French Caucasians from the DESIR (Data From an Epidemiological Study on the Insulin Resistance Syndrome) cohort."

R. Jaziri and colleagues at the Xavier...

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