Obesity and Diabetes Week

Genetics & Genomics - Chromosome 5 variations controls beta-cell mass expansion during hyperglycemia in mouse model

Obesity Complications - Obesity linked to increase in TVR after intent-to-stent percutaneous coronary intervention

Obesity Epidemiology - Mc3rKO and Mc4rKO reduced muscle oxidative metabolism and may indicate risk for weight gain

Obesity Pathogenesis - Farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

Obesity Therapy - Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis

Adipose Tissue - Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins

Adipose Tissue - Visfatin/pre-B cell colony-enhancing factor role in obesity reviewed

Alcohol Use - Alcohol consumption linked directly to circulating oxidized low-density lipoprotein

Anesthesia - Intravenous sedation maintains stable hemodynamic state regardless of BMI

Angiology - Bezafibrate attenuates progression of insulin resistance in coronary artery disease

Angiology - CD40 gene but not CD40L gene variants linked to coronary artery calcification

Blood Glucose - Colonic fermentation of indigestible carbohydrates contributes to second-meal effect

Business & Finance - Emisphere Technologies announces 2006 first quarter preliminary financial results

Business Update - Sontra introduces updated transdermal glucose monitoring, topical lidocaine delivery system

Business Update - USAN Council approves name lorcaserin hydrochloride for Arena drug candidate for obesity

Cachexia - Pathophysiology and clinical relevance of cachexia are reviewed

Cardiac Medical Devices - Conor Medsystems initiates RAPID clinical study for first pimecrolimus drug-eluting stent

Cardiomyocyte Diabetes - Cardiomyocytes diabetes alters adenosine metabolizing enzyme activities

Cardiovascular Disease - Metabolic syndrome predicts cardiac risk in families with a history of coronary artery disease

Cardiovascular Research - Signaling by angiotensin-converting enzyme is considered in review of recent evidence

Cell Physiology - SH2-B and APS differentially regulate energy and glucose homeostasis

Collaborations - AEterna Zentaris signs deal with the University of Montreal for obesity therapy

Colorectal Cancer - Exercise, diet may protect against colorectal cancer

Contracts - Matria Healthcare announces four new disease management accounts with self-insured employers

Contracts - Nutrition 21 receives commitment from Duane Reade for its Chromax and Diachrome products

Coronary Artery Disease - Angiotensin-converting enzyme inhibitors reduce mortality in CAD patients without heart failure

Diabetes & Alcohol Use - Chronic ethanol intake impairs insulin signaling by disrupting akt-cell membrane association

Diabetes & Candida - Antifungal susceptibility of Candida isolates from diabetes mellitus vary between centers

Diabetes & Candida - Oral Candida and isolate ability to enhance virulence are influenced by diabetes mellitus

Diabetes & Cardiology - Benidipine subdepressor dose eases diabetic cardiac remodeling in rat model

Diabetes & Cardiology - Vancomycin penetration into target tissues is impaired in diabetics after cardiac surgery

Diabetes & Heart Disease - Hemoglobin A_1c level linked to coronary artery disease severity in diabetes mellitus

Diabetes & Schizophrenia - Schizophrenia appears to have a negative impact on diabetes self-care

Diabetes Complications - Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance

Diabetes Complications - Insulin resistance and endothelial dysfunction reciprocal relationships reviewed

Diabetes Control - Chronic care model is effective in improving clinical and behavioral outcomes in diabetes

Diabetes Control - Diabetes and CVD preventive care suboptimal in Australian general practice

Diabetes Diagnostics - Fasting plasma glucose testing alone may be inadequate for prediabetes diagnosis

Diabetes Diagnostics - Initial detection of diabetes mellitus often requires glucose tolerance, not ADA scores

Diabetes Epidemiology - Diabetes processes of care and intermediate outcomes have improved in U.S.

Diabetes Pathogenesis - Diabetes may interfere with synthesis of nitric oxide of corpus cavernosum nerves and endothelium

Diabetes Pathogenesis - Low beta-cell activity and high insulin sensitivity found in stunted children

Diabetes Pathogenesis - p90 Ribosomal S6 kinase plays a key role in hyperglycemia-mediated myocardial PRECE induction

Diabetes Pathogenesis - Progression of PAI-1 and fibrinogen levels linked to incident type 2 diabetes

Diabetes Pathogenesis - ZO-1 expression and phosphorylation are likely involved in diabetic nephropathy pathogenesis

Diabetes Prevention -  Morus alba extracts show inhibitory effects on small intestine disaccharidase activity

Diabetes Research - Diabetes hits 275 Australians each day as pandemic spreads

Diabetes Research - Joslin-led study reveals new findings on insulin signaling in the liver

Diabetes Therapy - Acute myocardial infarction mortality not altered after insulin/dextrose infusion therapy

Diabetes Therapy - Angiotensin-converting enzyme inhibitor may improve coronary microangiopathy related to diabetes

Diabetes Therapy - Glucocentric approach to diabetes therapy should be changed to a vascular approach

Diabetes Therapy - Ramipril was linked to lower diabetes mellitus risk in hypertensive kidney disease

Diabetic Nephropathy - NephroGenex licenses Pyridorin for diabetic nephropathy and acute renal failure

Diabetic Nephropathy - Renal tissue renin-angiotensin system may be activated in human type 2 diabetic nephropathy

Diabetic Nephropathy - Smad1 expression is associated with mesangial matrix expansion in rat diabetic nephropathy

Diabetic Neuropathy - Intraepidermal nerve fiber loss cannot explain pain in all diabetic neuropathy cases

Diet & Nutrition - Carbohydrate balance predicts weight and fat gain in adults

Diet & Nutrition - Dietary fiber is protective against high C-reactive protein

Diet & Nutrition - Full-fat dairy and natural trans fatty acid intake did not alter cardiovascular disease risk

Diet & Nutrition - Processed carbohydrate intake has predominantly unfavorable effect on lipid profile

Drug Development - Acomplia recommended for approval in the European Union

Drug Development - Bile acids signaling pathways may provide novel drug targets for metabolic diseases

Drug Development - C-terminal aza-amino acid analogs of melanocortin receptor agonist may provide peptide mimics

Drug Development - Tranzyme reports positive results from phase 1 trial of ghrelin agonist for post-op ilius

Drug Development - Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes

Drug Eluting Stents - Sirolimus eluting stents are superior to paclitaxel in nondiabetics but not diabetics

Dyslipidemia - Cardiologists appear to have healthier lifestyles than general adult U.S. population

Endocrinology - Excess blood leptin does not diminish brain intranasal leptin uptake

Endocrinology - Platelet rich plasma may play a role in mediating diabetic fracture healing

Environmental Toxins - Adiposity affects human response to inhaled organic dust

Finance - ChemGenex completes $A15 million capital-raising

Finance - OSI Pharmaceuticals announces first quarter 2006 revenues of $116.4 million

Finance - U.S. Army awards $2 million initially to Lexicon Genetics to study spinal muscular atrophy

Fitness & Wellness - Veterans Specific Activity Questionnaire predicted all-cause mortality

Gastroenterology - Vascular growth prompts pancreatic beta-cell proliferation

Genetics & Genomics - Polymorphism in suppressor of cytokine signaling 2 gene linked to type 2 diabetes

HIV/AIDS Lipoatrophy - HAART-associated facial lipoatrophy corrected by polylactic acid implants

Hernias - Hernia repair in gastric bypass is safely done during redundant abdominal panniculus removal

Hyperglycemia - Insulin therapy improved survival in hyperglycemic septic model of critical illness

Medical Devices - New biosensor detects both total and glycated hemoglobin content in blood samples

Medical Devices - Omron 637IT wrist blood pressure measuring device is validated in adults and obese adults

Metabolic Syndrome - History of the metabolic syndrome is reviewed

Natural Products -  Rauwolfia vomitoria and Citrus aurantium show antidiabetic and lipid-lowering effects

Natural Products - Cinnamon eases sucrose-induced blood pressure elevations in spontaneously hypertensive rats

Natural Products - Cinnamon extract may reduce fasting glucose levels in diabetics with poor glycemic control

Obesity & Cardiac Disease - Myocardial lipid content may be a biomarker for cardiac disease in obese

Obesity Complications - Resistin appears to play a key role in obesity-related insulin resistance

Obesity Complications - Standard ertapenem dose may not provide adequate drug exposure for obese

Obesity Epidemiology - Genetic variants alter dopamine availability associated with obesity

Obesity Epidemiology - Japanese have higher percent body fat at lower BMI compared to Australian-Caucasian males

Obesity Management - Weight Watchers helps new moms shed extra weight

Obesity Measurements - Percent body fat seems to be a good indicator for evaluation of workplace obesity

Obesity Pathogenesis - Calcitriol may play role in promoting or inhibiting adipogenesis via vitamin D receptor

Obesity Pathogenesis - CREB activation induced by mitochondrial dysfunction causes triglyceride accumulation

Obesity Pathogenesis - Endocannabinoids and cannabinoid type 1 receptor play a role in energy balance control

Obesity Pathogenesis - Endogenous cannabinoid levels in brain and peripheral tissues control food intake

Obesity Pathogenesis - Hyperphagia, low body temperature, and reduced activity precede morbid obesity

Obesity Pathogenesis - Understanding dyslipidemia may reveal adipocyte role in maintaining metabolic homeostasis

Obesity Research - Cultural approach is key to tackling obesity

Obesity Research - Some people would give life or limb not to be fat

Obesity Therapy - CB1 receptor signaling mechanisms involving the endocannabinoid system reviewed

Obesity Therapy - Gastric electrical stimulation using endoscopically placed mucosal electrodes reduces food intake

Obesity Treatment - Vivus announces positive phase 2 clinical trial results with obesity treatment Qnexa