Published in Obesity and Diabetes Week, June 5th, 2006
According to a study from Japan, "Mutations in the hepatocyte nuclear factor (HNF)-4 alpha gene cause a form of maturity-onset diabetes of the young (MODY1) that is characterized by impairment of glucose-stimulated insulin secretion by pancreatic beta-cells. HNF-4 alpha, a transcription factor belonging to the nuclear receptor superfamily, is expressed in pancreatic islets as well as in the liver, kidney, and intestine. However, the role of HNF-4 alpha in...
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