Obesity and Diabetes Week

Diabetes Epidemiology - Impaired glucose tolerance and overweight risk is higher in children of mothers with GDM

Obesity Complications - Overweight Crohn disease patients require earlier surgical intervention

Obesity Pathogenesis - Adipose tissue distribution influences free fatty acid metabolism

Obesity Pathogenesis - Cytokine secretion by adipocytes regulated by adiponectin, AICAR, and troglitazone

Obesity Pathogenesis - FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity

Atherosclerosis - Myeloid lineage insulin resistance protects ApoE-deficient mice against atherosclerosis

Biomedical Engineering - Lactulose and mannitol intestinal permeability detected by capillary electrophoresis

Breast Cancer - Body mass index and hormone therapy interactions correlate with specific breast cancers

Breast Cancer - Most breast cancers coexpress leptin, although OBR-S is an independent prognostic factor

Cardiac Medical Devices - Coronary stent system cited in EuroIntervention for superiority in diabetic patients

Cardiac Medical Devices - Endeavor registry data confirms success in broad spectrum of patients

Cardiology - Adverse cardiovascular outcomes can be predicted by measuring abdominal adiposity

Cardiovascular Disease - Metabolic syndrome increases cardiovascular disease risk in older adults

Cardiovascular Disease - Voglibose therapy improved glycemic control and inhibited cardiac remodeling

Cardiovascular Research - Metabolic syndrome significantly boosts the risk of heart failure in middle age

Cardiovascular Research - Physicians do not view cardiovascular risks as reason to change blood pressure treatment

Cholecystectomy - Minilaparotomy cholecystectomy appears to be faster for uncomplicated gallstone disease

Clinical Trials - Biotec Pharmacon completes patient enrollment in phase II clinical trial for diabetic ulcers

Collaborations - Nanogen announces type 2 diabetes research collaboration with Oy Jurilab

Collaborations - Partnership to develop gene therapy for diabetic eye disease

Diabetes & Cardiovascular Disease - Endothelial dysfunction and inflammation explain excess cardiovascular mortality in diabetes

Diabetes & Geriatrics - Predictors of falls are determined for older rural adults with diabetes

Diabetes & Tuberculosis - Diabetes is a risk factor for tuberculosis

Diabetes Cardiomyopathy - Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes

Diabetes Complications - Antidiabetic drug metformin shows osteogenic effects on osteoblasts in culture

Diabetes Complications - Cyclin D1 signaling may be involved in impaired tissue repair

Diabetes Complications - Insulin receptor deficiency raises ER stress-induced apoptosis in atherosclerotic plaques

Diabetes Complications - Receptor for advanced glycation end-products suppresses nNOS expression in enteric neurons

Diabetes Complications - Type 2 diabetes increases the risk of all cause mortality in the U.K.

Diabetes Control - Glycemic control and education mediated by literacy in low-income people with diabetes

Diabetes Control - Therapy changes to improve hypertension, dyslipidemia, and diabetes mellitus control reviewed

Diabetes Epidemiology - Diabetes incidence is increasing in U.S. adults

Diabetes Epidemiology - Modifiable environmental risk factors for type 2 diabetes in school children identified

Diabetes Models - Lentiviral shRNA constructs provide approach to deliver siRNAs into 3T3-L1 adipocytes

Diabetes Neuropathy - Reduced nodal Na⁺ currents may add to human diabetic neuropathy

Diabetes Pathogenesis - Abnormal benzodiazepine system function explains DOI-HTRs suppression in diabetic model

Diabetes Pathogenesis - Akt/GSK-3 beta, p38MAPK, and calcineurin pathways may play a key role in IGF-1 signaling

Diabetes Pathogenesis - Diabetes exerts a large effect on intestinal cytochrome P450 enzyme activity

Diabetes Pathogenesis - Lack of erythropoietin production due to low hemoglobin is key component to diabetic anemia

Diabetes Pathogenesis - Office and ambulatory blood pressure are independently linked to albuminuria in type 2 diabetes

Diabetes Pathogenesis - PKC theta is a key player in the development of insulin resistance

Diabetes Pathogenesis - Role of hyperglycemia and oxidative stress in diabetes is reviewed

Diabetes Pathogenesis - Shock wave lithotripsy for renal and ureteral stones related to hypertension and diabetes

Diabetes Pathogenesis - Uncoupling protein 2 promoter polymorphism-866G/A affects peripheral nerve in diabetics

Diabetes Research - Rosiglitazone PPAR-gamma activation caused reduced inflammatory effects in pregnant diabetic model

Diabetes Therapy - Anterolateral thigh perforator flaps effective for diabetic foot reconstruction

Diabetes Therapy - Bitter yam sapogenin extract or diosgenin reduced intestinal disaccharidases in diabetes

Diabetes Therapy - Community health workers improve knowledge of people with diabetes

Diabetes Therapy - Glucagon-like peptide 1 based therapy show promise for type 2 diabetes therapy

Diabetes Therapy - Insulin detemir given twice daily showed constant metabolic effect under steady-state conditions

Diabetes Therapy - Metformin extended release was well tolerated in type 2 diabetes mellitus

Diabetes Therapy - Metformin improves blood pressure and endothelial function in aorta of diabetic rat model

Diabetes Therapy - Pioglitazone treatment improves nitrosative stress in type 2 diabetes

Diabetes Therapy - Rosiglitazone may downregulate UCP 2 expression leading to impaired insulin secretion

Diabetes Therapy - Valsartan improves resting skin blood flow in type 2 diabetics and reduces PPAR polymerase activation

Diabetes Therapy - Vildagliptin is a dipeptidyl peptidase-4 inhibitor with antidiabetic properties

Diabetic Foot Ulcer - Pedal bypass, flap plasty and vacuum therapy are effective for limb salvage in diabetic foot ulcers

Diabetic Nephrology - RASS inhibition linked to lower mortality risk and renal end point rate in diabetics

Diabetic Nephropathy - Prescription Hachimi-jio-gan improves diabetic nephropathy in type 2 diabetes model

Diabetic Neuropathy - Neurological complications of prediabetes needs to be more thoroughly explored

Diabetic Retinopathy - Neurodegeneration in diabetic retinopathy may arise from glucose-induced amino acid

Diet & Nutrition - B vitamins have no beneficial effect on asymmetric dimethylarginine levels

Diet & Nutrition - Calorie restriction improves insulin sensitivity by lowering fatty acid and triglycerides levels

Diet & Nutrition - U.N.'s Food and Agriculture Organization asserts agriculture policies can promote healthy diets

Diet & Nutrition - Vitamin D deficiency and secondary hyperparathyroidism risk is higher in obese Black Americans

Drug Development - Advanced Viral Research completes accrual in first part of diabetes study

Endocrinology - Endocrine pancreas can compensate for zinc deficiency but exocrine pancreas cannot

Endocrinology - Glut4 translocation to neuronal PM is regulated by insulin and leptin signaling pathways

Endocrinology - Hepatic AMPK alpha 2 isoform is key for regulating hepatic glucose and fasting glucose

Endocrinology - Insulin controls islet alpha-cell function by reducing K_ATP channel sensitivity

Endocrinology - Kinin B₁ receptor plays key role in insulin homeostasis and pancreatic islet function

Endocrinology - Monocyte chemotactic protein-1 may be involved in adipose tissue/skeletal muscle cross-talk

Endocrinology - Pancreas of young rats can regenerate beta-cell loss and may be linked to altered phenotypes

Endocrinology - Prohormone convertase 1/3 is needed for GIP precursor processing

Endocrinology - Rin1 regulates insulin receptor signal transduction pathways

Finance - MacroGenics raises $45 million in series C financing

Fitness & Wellness - Physical training linked to improved adiponectin and CRP levels in type 2 diabetics

Fitness & Wellness - Submaximal aerobic workout does not alter adiponectin/resistin levels up to 48 h postexercise

Gastroenterology - New technologies and safer options provide better results for GI disorders

Genetics & Genomics - Elevated glucose and diabetes promote interleukin-12 cytokine gene expression in macrophages

Genetics & Genomics - Signaling activations are involved in amphetamine-mediated appetite suppression

Hyperglycemia - Glucose-6-phosphate dehydrogenase and NADPH/NADP⁺ dependent on hyperglycemia severity

Hypertension - The angiotensin receptor antagonist valsartan is reviewed

Hypoglycemia - Total brain glycogen is glucosyl unit source during hypoglycemia and may be neuroprotective

Inflammation Biomarkers - Physical activity status influences inflammatory biomarkers and toll-like receptor 4

Islet Transplantation - Islets transplanted intraportally are stimulated exclusively through hepatic artery

Leg Ulcer Therapy - Vacuum-assisted closure after mesh-graft-transplant improved leg ulcer patient outcome

Marketing - Endocrine Society and Hormone Foundation offer free access to research, patient info from journals

Natural Products - Analysis of onion and garlic relating to common diseases is reviewed

Natural Products - Japanese radish sprout showed hypoglycemic activity and improved lipid metabolism in rats

Obesity Complications - Abdominal obesity is the most common cause of metabolic syndrome and cardiometabolic risk

Obesity Epidemiology - International Day for the Evaluation of Abdominal obesity to provide obesity prevalence map

Obesity Management - Thin-Link, HealthPartners to develop weight management program for HealthPartners employees

Obesity Surgery - Studies find bariatric surgery reduces downstream medical costs

Obesity Therapy - Bicyclic[4.1.0]heptanes as substitutes for melanin-concentrating hormone receptor antagonists may offer obesity therapy

Obesity Therapy - Telmisartan raises caloric expenditure and protects against weight gain and hepatic steatosis

Obstetrics - Prepregnancy diabetes care is important to reduce adverse obstetric outcomes

Oligonucleotide - Insulin can be captured by an insulin-linked DNA oligonucleotide

Personnel - Herbalife adds U.K. sports specialist Ralph Rogers, MD, PhD, to medical advisory board

Personnel - Novo Nordisk announces two new vice presidents of diabetes sales, Pamela Harris and Patrick Loustau