Diabetes Pathogenesis
Abnormal benzodiazepine system function explains DOI-HTRs suppression in diabetic model
Published in Obesity and Diabetes Week, June 12th, 2006
"We previously reported that the head-twitch responses induced by the 5-HT2 receptor agonist (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) (DOI-HTRs) were decreased in streptozotocin-induced diabetic mice. We examined the involvement of gamma-aminobutyric acid (GABA)/benzodiazepine system on the suppression of DOI-HTRs in diabetic mice," investigators in Japan report.
S. Miyata and colleagues working with Hoshi University discovered, "The benzodiazepine receptor antagonist flumazenil (0.1-1 mg/kg, i.v.)...
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