Endocrinology
Glut4 translocation to neuronal PM is regulated by insulin and leptin signaling pathways
Published in Obesity and Diabetes Week, June 12th, 2006
According to a study from France, "The insulin-sensitive glucose transporter Glut4 is expressed in brain areas that regulate energy homeostasis and body adiposity. In contrast with peripheral tissues, however, the impact of insulin on Glut4 plasma membrane (PM) translocation in neurons is not known."
"In this study," stated Y. Benomar and colleagues, University of Paris 11, "we examined the role of two anorexic hormones (leptin and insulin) on Glut4 translocation in a human neuronal cell line that express endogenous insulin and leptin...
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