Atherosclerosis
Myeloid lineage insulin resistance protects ApoE-deficient mice against atherosclerosis
Published in Obesity and Diabetes Week, June 12th, 2006
According to recent research published in the journal Cell Metabolism, "Inflammatory processes play an important role in the pathogenesis of vascular diseases, and insulin-resistant diabetes mellitus type 2 represents an important risk factor for the development of atherosclerosis. To directly address the role of insulin resistance in myeloid lineage cells in the development of atherosclerosis, we have created mice with myeloid lineage-specific inactivation of the insulin receptor gene."
"On an ApoE-deficient background, MphIRKO...
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