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Endocrinology

Monocyte chemotactic protein-1 may be involved in adipose tissue/skeletal muscle cross-talk

Published in Obesity and Diabetes Week, June 12th, 2006

Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.

"Adipose tissue is a major secretory and endocrine active organ producing a variety of bioactive proteins that may regulate energy metabolism and insulin sensitivity. In several studies, we have already shown that adipocyte-secretory products induce skeletal muscle insulin resistance. However, the precise nature of these factors has remained elusive," scientists writing in the journal Endocrinology report.

H. Sell and colleagues at the German Diabetes Center determined, "Human adipocytes were found to secrete various...

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