Diabetes & Obesity
Muscle activates lipid oxidation and stores the rest as intramyocellular lipid content
Published in Obesity and Diabetes Week, June 19th, 2006
"Intramyocellular lipid content (IMCL) serves as a good biomarker of skeletal muscle insulin resistance (IR). However, intracellular fatty acid metabolites [malonyl-CoA, long-chain acyl-CoA (LCACoA)] rather than IMCL are considered to be responsible for IR," scientists in Germany report.
"This study," proposed A. Beha and colleagues, sanofi-aventis Deutschland GMBH, "aimed to investigate dynamics of IMCL and fatty acid metabolites during fed-to-starved-to-refed transition in lean and obese (IR)...
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