Obesity Pathogenesis
Mice lacking adipose triglyceride lipase show defective lipolysis and altered metabolism
Published in Obesity and Diabetes Week, June 19th, 2006
"Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids (FFAs) from stored fat requires the enzymatic activity of lipases," scientists writing in the journal Science report.
"We showed that genetic inactivation of adipose triglyceride lipase (ATGL) in mice increases adipose mass and leads to triacylglycerol deposition in multiple tissues. ATGL-deficient mice accumulated large amounts of lipid in the heart, causing cardiac dysfunction and premature death. Defective cold adaptation indicated that the enzyme...
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