Published in Obesity and Diabetes Week, June 26th, 2006
"The goal of this investigation was to determine whether there are sex-related differences in the development of cardiomyocyte dysfunction in prediabetic, insulin-resistant animals. Male and female rats were maintained on a high-sucrose diet for 5-11 weeks, and mechanical properties of isolated ventricular myocytes were measured by high-speed video edge detection. Several in vitro interventions were used to manipulate intracellular Ca2+ in order to determine whether altered Ca2+ availability contributes to the cardiomyocyte dysfunction," investigators in the...
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