Stem Cell Research
Angiogenic factors and transduction protein confer differentiation properties to endothelial cells
Published in Obesity and Diabetes Week, July 3rd, 2006
According to recent research from Sweden, "The potential use of embryonic stem (ES) cells for cell therapy of diabetes requires improved methods for differentiation and isolation of insulin-producing beta-cells. The signal transduction protein SHB may be involved in both angiogenesis and beta-cell development."
"Here we show that cells expressing the pancreatic endodermal marker PDX-1 appear in the vicinity of vascular structures in ES cell-derived embryoid bodies (EBs) cultured in vitro. Moreover, overexpression of SHB as well as culture of EBs in...
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