Obesity Pathogenesis
Leptin may inhibit preadipocyte proliferation by modifying signals in nonadipose tissue
Published in Obesity and Diabetes Week, July 3rd, 2006
According to a study from the United States, "Leptin has been shown to reduce body fat in vivo. Adipocytes express the leptin receptor; therefore, it is realistic to expect a direct effect of leptin on adipocyte growth and metabolism. In vitro studies examining the effect of leptin on adipocyte metabolism require supraphysiological doses of the protein to see a decrease in lipogenesis or stimulation of lipolysis, implying an indirect action of leptin. It also is possible that leptin reduces adipose mass by inhibiting preadipocyte proliferation (increase...
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