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Diabetes Pathogenesis

PPARG agonist rosiglitazone can elevate ADIPOR2 expression in hepatocytes

Published in Obesity and Diabetes Week, July 3rd, 2006

PPARG agonist rosiglitazone can elevate the expression of ADIPOR2 in hepatocytes.

"Adiponectin is an adipocyte-derived hormone that plays a critical role in the development of type 2 diabetes via interaction with adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2). Rosiglitazone is a peroxisome proliferator-activated receptor-gamma (PPARG) agonist that is widely used in the treatment of type 2 diabetes. We hypothesized that rosiglitazone regulates lipid and glucose metabolism through modulation of the expression of adiponectin receptors in the liver," scientists in People's Republic of China report.

X. Sun and colleagues at the Chinese Academy of...

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