Published in Obesity and Diabetes Week, July 3rd, 2006
According to recent research from the United States, "The 5-HT2C receptor has been implicated in the regulation of appetite."
"As such, small molecule agonists to this receptor may serve as novel therapies to combat obesity. We describe here the identification, synthesis, and SAR of a 5-HT2C agonist from a unique pyrimidine-diazabicyclo[3.3.0]octane series," wrote B.R. Huck and colleagues, Athersys Inc.
The researchers concluded, "This compound displayed good potency at the 5-HT2C receptor, modest selectivity relative to other 5-HT2...
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