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Diabetes Therapy

Candesartan protects beta-cell function in diabetes mouse model

Published in Obesity and Diabetes Week, July 10th, 2006

Candesartan, an angiotensin II type I receptor blocker, protects beta-cell function in db/db mice.

"Several epidemiological studies suggested that treatment with angiotensin II type 1 receptor blocker (ARB) provided a risk reduction of developing type 2 diabetes. In this study, we investigated whether and how ARB treatment can improve abnormalities of pancreatic islets in diabetes state," scientists writing in the journal Biochemical and Biophysical Research Communications report.

J.Q. Shao and colleagues at Juntendo University explained, "We randomized db/db mice, a model of type 2 diabetes with obesity, at the age of 8 weeks to receive...

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