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Arteriogenesis

Hypercholesterolemia lowers arteriogenesis more strongly than hyperglycemia or hyperinsulinemia

Published in Obesity and Diabetes Week, July 10th, 2006

Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice.

According to recent research published in the journal Arteriosclerosis Thrombosis and Vascular Biology, "Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by vascular risk factors, eg, diabetes or hypercholesterolemia."

"Here," proposed V. van Weel and colleagues, TNO Biomedical Research., "we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis."

They...

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