Published in Obesity and Diabetes Week, July 17th, 2006
"Bcl-6, a major regulator of B lymphocyte function that contributes to neoplastic transformation of B cells, is expressed in activated germinal center (GC) B cells and down-regulated during terminal differentiation to plasma cells. Regulation of Bcl-6 expression is incompletely characterized," wrote S.C. Lee and colleagues, Juvenile Diabetes Research Foundation International.
"Terminal B cell differentiation is associated with down-regulation of Bcl-6, activation of Blimp-L modulation of Myc, and specifically with the up-regulation of the Mad1 and Mad4...
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