Allergy & Immunology
Mad1 is a transcriptional repressor of Bcl-6
Published in Obesity and Diabetes Week, July 17th, 2006
"Bcl-6, a major regulator of B lymphocyte function that contributes to neoplastic transformation of B cells, is expressed in activated germinal center (GC) B cells and down-regulated during terminal differentiation to plasma cells. Regulation of Bcl-6 expression is incompletely characterized," wrote S.C. Lee and colleagues, Juvenile Diabetes Research Foundation International.
"Terminal B cell differentiation is associated with down-regulation of Bcl-6, activation of Blimp-L modulation of Myc, and specifically with the up-regulation of the Mad1 and Mad4...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
More Articles from Obesity and Diabetes Week
- Diabetes & Obesity
Obesity correlates to elevated plasma C-reactive protein levels in metabolic syndrome - Diabetes Complications
Melatonin lowers glucose levels and partly restores pancreatic beta-cells in diabetes model - Diabetes Therapy
Vanadyl(IV) ions act on glucose metabolism sites in adipocytes improving blood glucose levels - Obesity Epidemiology
Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse - Angiology
Vascular biosynthesis of tetrahydrobiopterin increases in apolipoprotein E-deficient mice - Anti-Inflammatory Agent
Pigment epithelium-derived factor inhibits AGE-induced CRP expression in hepatoma cells - More from this issue of Obesity and Diabetes Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
