Drug Research
Metformin raises GLUT4 residence time in plasma membrane by through a reduction in endocytosis
Published in Obesity and Diabetes Week, July 17th, 2006
According to recent research from England, "Long-term (18 h) metformin treatment of cardiomyocytes increased glucose transport activity 3- to 5-fold, as measured using the phosphorylated sugar 2-deoxy-D-glucose and the nonphosphorylated sugar 3-O-methyl-D-glucose."
J. Yang and colleagues at the University of Bath observed, "The affinity for 3-O-methyl-D-glucose transport was not increased by metformin treatment. Total levels of glucose transporter 4 (GLUT4) were not changed by 18-h...
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