Angiology
Vascular biosynthesis of tetrahydrobiopterin increases in apolipoprotein E-deficient mice
Published in Obesity and Diabetes Week, July 17th, 2006
"Previous studies suggested that loss of tetrahydrobiopterin (BH4 ) may play an important role in the pathogenesis of vascular endothelial dysfunction induced by diabetes and hypertension. In contrast, controversial results have been reported regarding BH4 metabolism in experimental models of atherosclerosis. Therefore, the present study was designed to characterize the expression and activity of GTP-cyclohydrolase I, a rate-limiting enzyme in biosynthesis of BH4 , during atherogenesis," scientists writing in the American Journal of Physiology...
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