Diabetes Pathogenesis
Enzyme mutation perturbs insulin secretion
Published in Obesity and Diabetes Week, July 24th, 2006
"GDH plays an important role in insulin secretion as evidenced in children by gain of function mutations of this enzyme that cause a hyperinsulinism-hyperammonemia syndrome (GDH-HI) and sensitize beta-cells to leucine stimulation.
"GDH transgenic mice were generated to express the human GDH-HI H454Y mutation and human wild-type GDH in islets driven by the rat insulin promoter," wrote C.H. Li and colleagues, Children's Hospital of Philadelphia.
"H454Y transgene expression was confirmed by...
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