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Obesity Pathogenesis

Uncoupling protein-3 prevents triglyceride build-up in adipose tissue and muscle

Published in Obesity and Diabetes Week, July 24th, 2006

Uncoupling protein-3 prevents triglyceride build-up in both adipose tissue and skeletal muscle.

According to recent research from Canada, "Uncoupling protein-3 (UCP3) is a poorly understood mitochondrial inner membrane protein expressed predominantly in skeletal muscle. The aim of this study was to examine the effects of the absence or constitutive physiological overexpression of UCP3 on whole body energy metabolism, glucose tolerance, and muscle triglyceride content."

S.R. Costford and colleagues at the University of Ottawa explained, "Congenic male UCP3 knockout mice (Ucp3-/-), wild-type, and transgenic UCP3 over-expressing (UCP3Tg) mice...

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