Obesity and Diabetes Week

Diabetes & Obesity - Calpain-10 polymorphisms contribute to diabetes risk by regulating abdominal obesity

Diabetes & Obesity - Novel cyanopyrrolidine analogues show diabetes and obesity therapy potential

Diabetes & Obesity - PPAR alpha improves pancreatic adaptation to insulin resistance and reduces lipotoxicity

Diabetes Epidemiology - Hepatic lipase gene variant impacts coronary heart disease risk differently in obese diabetics

Diabetes Therapy - alpha-Lipoic acid regulates AMP-activated protein kinase

Allergy & Immunology - beta cell autoimmunity linked to introduction age of fruits, berries and roots

Angiology & Obesity - Sibutramine therapy is associated with weight loss and improved endothelial function

Antipsychotics - Chronic olanzapine induces metabolic and food intake alterations in mouse model

Blood Glucose - Glucose from subcutaneous adipose tissue can monitor glycemic control after cardiac surgery

Business Update - UniCare implements benefits programs to identify and support people with chronic conditions

Coronary Heart Disease - Heart disease, diabetes risk may be increased in women with hyperapobetalipoproteinemia

Diabetes & Atherosclerosis - Higher soluble CD40 ligand levels linked to carotid atherosclerosis in type 1 diabetes

Diabetes & Depression - In type 2 diabetes, depression therapy and prevention improve health-related quality of life

Diabetes & Heart Disease - Atorvastatin 80 mg reduced cardiovascular event rate in coronary heart disease with diabetes

Diabetes & Heart Disease - Coronary heart disease prediction score was developed for type 2 diabetes

Diabetes & Heart Disease - Moderately high-fat diet led to metabolic syndrome but did not alter myocardial infarct

Diabetes & Hemochromatosis - Diabetes and impaired glucose tolerance are common in hereditary hemochromatosis

Diabetes & Obesity - Metformin improved body composition and fasting insulin in obese insulin-resistant children

Diabetes & Tuberculosis - Diabetes mellitus strongly associated with tuberculosis in Indonesia

Diabetes Complications - Cognition in older type 1 diabetes patients is only mildly disturbed

Diabetes Complications - Diuretics and beta-blockers may accelerate type 2 diabetes development in hypertension

Diabetes Complications - Insulin users have higher hypertension risk in adult type 2 diabetes mellitus

Diabetes Complications - Interleukin deficiency leads to hyperphagia, obesity, and insulin resistance

Diabetes Complications - Islet changes in nonobese type 2 diabetes model develop similar to microangiopathy

Diabetes Complications - Panel of experts updates guidelines for use of KCI's V.A.C. diabetic foot therapy

Diabetes Control - 1,5-Anhydroglucitol reflects postprandial hyperglycemia and may be glycemic control marker

Diabetes Epidemiology - Hepatocyte nuclear factor-4 alpha gene P2 promoter haplotype linked to late-onset diabetes

Diabetes Epidemiology - Hepatocyte nuclear factor-4 alpha gene P2 promoter mutation linked to late-onset diabetes

Diabetes Epidemiology - HLA genotyping supports nonautoimmune etiology in diabetes diagnosed under 6 months of age

Diabetes Epidemiology - HLA-A24, -DQA1*03, and -DR9 trio linked to acute-onset beta-cell destruction in diabetes

Diabetes Epidemiology - p66^Shc deletion protects against diabetic glomerulopathy

Diabetes Management - Nine Minnesota, Wisconsin healthcare systems earn cash rewards for optimal diabetes care

Diabetes Pathogenesis - Apoptosis signal-regulating kinase 1 mediates glucose-induced aging in endothelial cells

Diabetes Pathogenesis - Dietary fat intake predicts 1-year change in body fat in adolescent girls with type 1 diabetes

Diabetes Pathogenesis - Diurnal rhythm in endogenous glucose production drive fasting hyperglycemia in diabetes

Diabetes Pathogenesis - F35V channels were inhibited by sulfonylurea therapy improving symptoms of neonatal diabetes

Diabetes Pathogenesis - Fat before carbohydrate meal slows gastric emptying and eases glycemic response in diabetes

Diabetes Pathogenesis - Glucose regulates Foxo1 through insulin receptor signaling in pancreatic islet beta cell

Diabetes Pathogenesis - High cord insulin and leptin levels are common in children of diabetic mothers

Diabetes Pathogenesis - PGC-1 alpha, estrogen-related receptor-alpha, or mitofusion 2 path changes may raise diabetes risk

Diabetes Pathogenesis - Reactive oxygen species may assist in protecting beta cells from autoimmune destruction

Diabetes Pathogenesis - Retinol-binding protein 4 is higher before diabetes and may be an insulin resistance marker

Diabetes Prevention - Diabetes Prevention Program cost sharing may give financial returns in long-term

Diabetes Prevention - High-risk individuals are reluctant to pay full price for diabetes risk-reduction programs

Diabetes Research - Adiponectin suppresses reactive oxygen species in vascular endothelial cells

Diabetes Research - Compromised transitional B cell generation in diabetic mouse yields relaxed selection

Diabetes Therapy - Angiotensin converting enzyme inhibitor lowers cardiovascular oxidative stress

Diabetes Therapy - Basal insulin plus oral drug therapy achieves guideline-recommended HbA_1c values

Diabetes Therapy - Diabetes risk does not appear to significantly increase with antipsychotic drugs

Diabetes Therapy - Dipeptidyl peptidase-4 inhibition preserves pancreatic beta-cell mass in diabetes model

Diabetes Therapy - Lisofylline analogs offer potential treatment options for type 1 diabetes

Diabetes Therapy - New study shows cinnamon extract lowers blood sugar levels in people with type 2 diabetes

Diabetes Therapy - Premeal inhaled human insulin improves glycemic control in poorly controlled type 2 diabetes

Diabetes Therapy - Selective AMPK in ventromedial hypothalamus activation may offer type 1 diabetes therapy

Diabetes Therapy - Urinary N-acetyl-Ser-Asp-Lys-Pro may be a biomarker for assessing ACE inhibition therapies

Diabetic Dyslipidemia - Function of very low-density lipoprotein in diabetic dyslipidemia is reviewed

Diabetic Nephropathy - Diabetic nephropathy is linked to oxidative phosphorylation gene expression

Diabetic Nephropathy - Endothelial NO synthase targeting and caveolin-1 expression are altered in diabetic kidney

Diabetic Nephropathy - Fibrogenic activity in diabetic nephropathy is abated by antiangiogenic protein

Diabetic Nephropathy - Low-level lead exposure accelerates progressive diabetic nephropathy

Diet & Nutrition - Calorie restriction reversed lipid deposition in tissues preventing insulin resistance

Diet & Nutrition - Large trial shows Mediterranean-style diet cuts heart attack risk better than low-fat diet

Diet & Nutrition - Levan hypolipidemic effects result from altered lipogenic enzyme and PPAR alpha gene activity

Diet & Nutrition - Normal-weight adults consume more fiber and fruit than overweight/obese peers

Diet & Nutrition - UCLA study shows how group dynamics affect fitness, eating habits

Endocrinology - Adiponectin, AdipoR1, and AdipoR2 linked to insulin sensitivity and metabolic parameters

Endocrinology - Adiposity hormones and inflammatory markers may predict cardiovascular death

Endocrinology - American Heart, Diabetes associations release new perspective on metabolic syndrome

Endocrinology - Decreasing adiponectin levels in growing youth may be due to gender type and body fat

Endocrinology - Glucose-6-phosphatase in liver helps control blood glucose in obese diabetic mouse model

Endocrinology - Glucose-dependent insulinotropic polypeptide NMR and alanine scans identify peptide activity

Endocrinology - High abdominal adiposity and insulin resistance at 2-4 years follow catch-up weight gain

Endocrinology - Inhibiting endogenous cortisol blunts meal-entrained rise in serum leptin

Endocrinology - Short-term insulin changes do not show regulatory effects on postprandial lipemia

Endometrial Cancer - Young endometrial cancer patients are usually more obese but elderly show more complications

Enzyme Inhibition - Beta-hydroxysteroid dehydrogenase inhibitors discovered

Fitness & Wellness - Fitness was inversely and BMI was directly related to nonalcoholic fatty liver disease

Fitness & Wellness - Phosphorylation of Akt substrates AS160 and filamin A in muscle increases after exercise

Fitness & Wellness - Weight status and physical activity patterns in adolescence predict adult weight and activity

Genetics & Genomics - Locus on chromosome 3q contributes to variations in plasma adiponectin

HIV/AIDS Wasting - Treatments are available that may counteract muscle wasting in HIV/AIDS

Legal Issues - Novo Nordisk prevails in sanofi-aventis challenge to Levemir insulin therapy

Licensing Agreements - Genetic company Ryogen LLC licenses human aminopeptidase P gene patent to R&D Systems

Mental Disorders - Higher waist circumference does not correlate to an increased risk of depressive disorders

Natural Products - Soy protein intake may help control diseases mediated by lipid disorders

Nephrology - Aldose reductase may be essential for maturation of the urine concentrating mechanism

Nephrology - Cystatin-C-based glomerular filtration rate estimates had same potential as accepted formulas

Obesity & Atherosclerosis - Plaque progression in obese patients attenuated using an intensive lipid-lowering strategy

Obesity & Cardiology - Rise in left ventricular mass in obese exceeds that required to match higher hemodynamic load

Obesity Complications - Higher macrophage infiltration in omental adipose tissue of obese linked to hepatic lesions

Obesity Complications - Insulin resistance syndrome is more prevalent than metabolic syndrome in obese children

Obesity Complications - LOX-1 appears to exacerbate oxidant stress and glomerulosclerosis in obesity models

Obesity Complications - Metabolic syndrome and insulin resistance linked to high C reactive protein and ferritin

Obesity Complications - Obesity is related to functional decline in peripheral arterial disease

Obesity Pathogenesis - Angiotensin II-induced tissue perfusion and metabolism changes similar in lean and obese

Obesity Pathogenesis - Hormone sensitive lipase shows regulation by obesity

Obesity Pathogenesis - Obesity negatively effects growth hormone secretion and reduces secretion by 25%

Obesity Pathogenesis - Serum uric acid may be an obesity-related indicator in early adolescence

Obesity Research - Sleep deprivation doubles risks of obesity in both children and adults

Obesity Therapy - Manhattan doses first patient group in phase 2a trial for oral obesity drug candidate

Obstetrics - Pregnancy-related adiponectin changes may be associated with glucose regulation

Orthopedics - Orthopedic surgeons must identify needs of obese patients as weight takes toll, paper says

Overweight Complications - Overweight youth report more fractures, musculoskeletal discomfort and impaired mobility

Pediatric Asthma - Vigorous, not moderate, physical activity inhibited by asthma

Personnel - Spherix elects eight directors, reports progress on anti-diabetes drug approvals, trial

Proteomics - c-Jun N-terminal kinase inhibitors with minimal cross-kinase activity were developed