Diabetes Pathogenesis
Adiponectin suppresses high-glucose-induced reactive oxygen species
Published in Obesity and Diabetes Week, August 7th, 2006
"Adiponectin is an abundant adipocyte-derived plasma protein with antiatherosclerotic effects. Vascular signal transduction by adiponectin is poorly understood and may involve W-AMP-activated protein kinase (AMPIC), cAMP signaling, and other pathways," wrote R. Ouedraogo and colleagues, Thomas Jefferson University.
They continued, "Hyperglycemia sharply increases the production of ROS, which play a key role in endothelial dysfunction in diabetes. Because the recombinant globular...
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