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Diabetes Pathogenesis

Postprandial lipemia induces a decrease of insulin sensitivity independent of NEFA levels

Published in Obesity and Diabetes Week, August 7th, 2006

Postprandial lipemia induces an acute decrease of insulin sensitivity in healthy men independently of plasma NEFA levels.

"Typical Western diets cause postprandial lipaemia for 18 h per day. We tested the hypothesis that postprandial lipaemia decreases insulin sensitivity. Employing a randomised crossover design, we administered two types of virtually isocaloric meals to ten healthy volunteers on two separate occasions," scientists writing in the journal Diabetologia report.

M.T. Pedrini and colleagues at the Medical University of Innsbruck described, "The meals (Meals 1 and 2) were both designed to produce a rise in triglycerides, but only...

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