Published in Obesity and Diabetes Week, August 14th, 2006
Study 1: Galactin-3 plays a key role in immune-mediated beta-cell destruction in type 1 diabetes.
"Proapoptotic cytokines are toxic to the pancreatic beta-cells and have been associated with the pathogenesis of type I diabetes (T1D). Proteome analysis of IL-1beta exposed isolated rat islets identified galectin-3 (gal-3) as the most upregulated protein. Here analysis of human and rat islets and insulinoma cells confirmed IL-1 beta regulated gal-3 expression of several gal-3 isoforms and a complex in vivo expression profile during diabetes development in rats,"...
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