Obesity
New findings from the United States and France in the area of obesity described
Published in Obesity and Diabetes Week, August 14th, 2006
Study 1: Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker.
"We have reported recently that the renal angiotensin II type 2 (AT2 ) receptors are upregulated and involved in promoting natriuresis/diuresis in obese but not in lean Zucker rats. In the present study, we tested the hypothesis that there is an enhanced AT2 receptor signaling via NO/cGMP pathway leading to greater inhibition of the Na+,K+-ATPase (NKA) activity in the proximal tubules (PT) of...
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