Published in Obesity and Diabetes Week, August 14th, 2006
"The serine/threonine phosphatase calcineurin is an important signaling molecule involved in kidney development and function. One potential target of calcineurin action is the water channel aquaporin 2 (AQP2). In this study, we examined the effect of loss of calcineurin A alpha (CnA alpha) on AQP2 function in vivo," researchers in the United States report.
J.L. Gooch and colleagues at Emory University found, "CnA alpha null mice were found to have defective postnatal urine-concentrating ability and an impaired urine-concentrating response...
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