Diabetic Retinopathy
Human retinal epithelium produces and responds to placenta growth factor
Published in Obesity and Diabetes Week, August 14th, 2006
According to a study from Germany, "PlGF is an important co-factor in retinal neovascularization. To examine whether retinal pigment epithelial (RPE) cells may represent a source for PlGF during retinopathy, we determined whether human RPE cells in vitro produce and respond to PlGF."
"In addition, we determined whether the cells express receptors for PlGF, i.e. flt-1 and neuropilins. Cultured human RPE cells of passages 3-5 were used. The regulation of the PlGF gene and protein expression by growth factors and cytokines was evaluated by quantitative...
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