Obesity Pathogenesis
PPAR gamma recruits positive transcription elongation factor b to promote adipogenesis
Published in Obesity and Diabetes Week, August 21st, 2006
According to a study from France, "Positive transcription elongation factor b (P-TEFb) phosphorylates the C-terminal domain of RNA polymerase II, facilitating transcriptional elongation. In addition to its participation in general transcription, P-TEFb is recruited to specific promoters by some transcription factors such as c-Myc or MyoD. The P-TEFb complex is composed of a cyclin-dependent kinase (cdk9) subunit and a regulatory partner (cyclin T1, cyclin T2, or cyclin K)."
In the present...
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