Published in Obesity and Diabetes Week, August 21st, 2006
Study 1: Diabetes-induced peripheral sensitization could be due to a local peripheral release of CCK-8.
According to recent research from Mexico, "The possible pronociceptive role of peripheral cholecystokinin (CCK-8) as well as CCKA and CCKB receptors in diabetic rats was assessed. Subcutaneous injection of 0.5% formalin induced a greater nociceptive behavior in diabetic than in non-diabetic rats."
"Moreover," reported I.E. Juarez-Rojop and colleagues, University Juarez Autonoma Tabasco, "local peripheral injection of CCK-8 (0.1-100 mcg) significantly...
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