Diabetes Pathogenesis
Reg family gene activation by in diabetic mouse pancreas plays a role in islet regeneration
Published in Obesity and Diabetes Week, August 28th, 2006
"We have recently reported that Pdx1-Cre-mediated whole pancreas inactivation of IGF-I gene [in pancreatic-specific IGF-I gene-deficient (PID) mice] results in increased beta-cell mass and significant protection against both type 1 and type 2 diabetes. Because the phenotype is unlikely a direct consequence of IGF-I deficiency, the present study was designed to explore possible activation of proislet factors in PID mice by using a whole genome DNA microarray," scientists writing in the American Journal of Physiology - Endocrinology and...
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