Diabetes Pathogenesis
Sodium arsenite impairs insulin secretion and transcription in pancreatic beta-cells
Published in Obesity and Diabetes Week, August 28th, 2006
"Human studies have shown that chronic inorganic arsenic (iAs) exposure is associated with a high prevalence and incidence of type 2 diabetes. However, the mechanism(s) underlying this effect are not well understood, and practically, there is no information available on the effects of arsenic on pancreatic beta-cells functions," researchers in Mexico report.
"Thus," wrote A. Diaz-Villasenor and colleagues, National Autonomous University of Mexico, "since insulin secreted by the pancreas plays a crucial role in maintaining glucose homeostasis, our aim was to...
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