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Endocrinology

Improved body weight and AMP-activated kinase activity may be leptin dependent in mouse model

Published in Obesity and Diabetes Week, August 28th, 2006

Low body weight and enhanced muscle AMP-activated kinase activity is likely leptin dependent in mouse model.

According to recent research from the United States, "Fatty acid-binding proteins (FABPs) are cytosolic fatty acid chaperones that play a critical role in systemic regulation of lipid and glucose metabolism. In animals lacking the adipocyte/macrophage FABP isoforms aP2 and mall, there is strong protection against diet-induced obesity, insulin resistance, type 2 diabetes, fatty liver disease, and hypercholesterolemic atherosclerosis."

H. Cao and colleagues at Harvard University determined, "On high-fat diet, FABP-deficient mice also exhibit...

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