Endocrinology
Mitochondrial reactive oxygen species required for hypothalamic glucose sensing
Published in Obesity and Diabetes Week, August 28th, 2006
"The physiological signaling mechanisms that link glucose sensing to the electrical activity in metabolism-regulating hypothalamus are still controversial. Although ATP production was considered the main metabolic signal, recent studies show that the glucose-stimulated signaling in neurons is not totally dependent on this production," scientists in France report.
"Here," proposed C. Leloup and colleagues, Institut L Bugnard, "we examined whether mitochondrial reactive oxygen species (mROS), which are physiologically generated depending on glucose metabolism, may act...
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