Nephrogenic Diabetes Insipidus
Vasopressin type-2 receptor and aquaporin 2 role in nephrogenic diabetes insipidus is reviewed
Published in Obesity and Diabetes Week, September 4th, 2006
"In the renal collecting duct, water reabsorption is regulated by the antidiuretic hormone vasopressin (AVP). Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the prourine to the interstitium," investigators in Netherlands report in their review.
"The disorder nephrogenic diabetes insipidus (NDI) is characterized by the kidney's inability to concentrate prourine in response to AVP, which is mostly acquired due...
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