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Obesity Complications

Obesity raises CD68 and TNF-alpha and lowers adiponectin gene expression in adipose tissue

Published in Obesity and Diabetes Week, September 4th, 2006

Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue.

"Both acquired and genetic factors regulate adipose tissue function. We determined whether adipose tissue mRNA expression is regulated by obesity, independently of genetic effects, by studying monozygotic (MZ) twins. Seventeen healthy pairs of MZ twins aged 24-27 yr (body mass index 20.0-33.9 kg/m2, intrapair differences in body weight 0.1-24.7 kg), were identified from the population-based FinnTwin16 cohort," scientists writing in the Journal of Clinical Endocrinology and Metabolism report.

K.H. Pietilainen...

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